EURO-ECO 2008Hanover18 - 20 November 2008 |
Environmental and Engineering Aspects for sustainable living |
European Academy of Natural Sciences, HanoverEuropean Scientific Society, HanoverUniversity of Bremen, Bremen |
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| M.I. Shtilman A.A. Artyukhov A.N. Kuskov | THE NEW POLYMERIC BIOMATERIALS FOR LIFE SCIENCES AND TECHNOLOGIES |
| D.I.Mendeleyev University of Chemical Technology of Russia, Research and Teaching Center “Biomaterials”, Moscow, Russia shtilmanm@yandex.ru |
The present-day development of medicine and other sciences and technologies connected with human health requires creation of new highly-effective and harmless materials which allow to broaden possibilities of surgical, therapeutic and bio-analytical methods and systems. The novel biomaterials for medicine and biotechnology are observed in report.
In this study novel method of creation of macromolecular materials for medical application on the basis of cross-linked macroporous hydrogels is proposed. Investigation of interaction of synthesized hydrogels with living organism tissues showed that introduction of developed preparation do not provoke inflammatory reaction on the initial stages of traumatic process and during the long-term contact novel hydrogels biodegrades fully with their substitution by conjunctive tissue. High biocompatibility, biodegradation with adjusted speed, good mechanical properties, stability under the conditions of application of standard sterilization methods, ability to sorb considerable amounts of liquids including salt solutions without changing of volume characteristics, availability of parent substances and of preparation methods allowed to propose obtained materials for medical application, especially in thoracic surgery, for treating of trophic ulcers and burns, in cosmetic surgery, for creation of therapeutic systems with controlled release of active substance and in several other areas.
The new polymer systems for drug systems were carried out on the base amphiphilic water soluble macromolecular systems. These polymers can form aggregates in water solutions with the average size between 50 and 200 nm and narrow size distribution as follows from the particle size measurement. The influence of polymer molecular weight on critical concentration of aggregation was studied. Prepared systems were tested as the polymer carriers for different drugs as the polymers with own bioactivity.
