The problem of the body exposure to the ecological hazards is extremely acute at the modern stage of the development of the human population. The body exposure to the toxic substances with different physical and chemical parameters gives way to endogen intoxication displayed in toxins accumulation in the internal environment of the body. Therefore one of the most important problems of the modern biological science is search and approbation of ecologically clean means belonging to the body internal environment due to the lymph system.

Objective: to study the peculiarities of structural organisation of submaxillary lymph node after intoxication with chlorous cadmium and its correction with Tagansorbent.

Materials and Methods: as research material submaxillary lymph node of white rats, Wistar breed was investigated. Cadmium chloride was used to create the experimental model of chronic intoxication. Daily within 2,5 months 8-9 a.m. to the standard vivar ratio cadmium chloride was added in the proportion of 1,5 mg per 1 kg of the weight. There were 3 groups of the animals: the first one – a control group, the second – with exotoxicosis, the third one – in the conditions of enterosorption (daily during 30 days 1gr of Tagan-sorbent per 1 kilo of the weight was added to the food). All groups of the animals were studied on 1, 7, 14, 21 day after the end of experimentally induced chronic intoxication with chlorous cadmium for 2,5 months and the correction of structural changes with Tagansorbent.

After decapitation the material was fixed in the solution (Telesnitsky). In the fixator the material was kept during 24 hours after that it was put into the 1st solution (70% ethyl alcohol). The samples were prapared conventionally. The organs were embedded in paraphin blocks contaning 5-6% of pure wax. The sliding microtome was employed to prepare paraphine cuts 5-6 mkm thick. The cuts were dyed with Meyer hematoxylin and eosin, azure ІІ- eosin (Eliseev and other, 1967; Lakhminarasimhan, Ridwaj, 1986). Dyed preparations were put into the Canadian balm.

Results: The investigation of the structure of submaxillary lymph node in the 1st day after cadmium chloride induction revealed dystrophic changes in cytoplasm and cellular edema in endoteliocites of the metabolism-related microvessels in all studied animals. In the animals that after cadmium chloride induction were given Tagansorbent there were similar findings to the mentioned above. In 7 days the dystrophic changes in cytoplasm and cellular edema were observed. A significant edema and widening of interstitial spaces was also reported. Practically no dynamics was seen by this period in the animals administered to Tagansorbent. In 14 days there were dystrophic changes in cytoplasm and cellular edema in endoteliocites of metabolism-related microvessels in all studied animals. More severe edema and widening of interstitial spaces were characteristic of the 1st group of the animals not administered to Tagansorbent. In 21 days features of edema in endoteliocites of metabolism-related microvessels in all studied animals were still observed. In the utmost degree the process of swelling and widening of interstitial spaces was manifested in the first group, where Tagansorbent was not given. Treatment with Tagansorbent during 21 days produced a protective effect on the structural-functional organisation of endoteliocites of blood capillaries in submaxillary lymph nodes – the swelling processes in cells disappeared.

Conclusion: 21-day treatment with Tagansorbent produced a protective effect on the structural-functional organisation of the submaxillary lymph node.