In experimental conditions during pro-longed physical activity for untrained animals with a strong type it is significant the increasing of emotionality and uneasiness whereas for weak type animals and partly-intermediate type there is a gradual development of depression on the background of full emotional areactivity. Time of grooming behavior has considerably increased in last 2 groups, as one of the processes of congenital behaviour for emotional pressure decreasing.

Physical activity causes an activation of neurohumoral systems referring to stressor (activating and potentiation parts) regulation of physiological and metabolic processes. The most mobile and quickly reacting is sympatho-adrenal system (its hormonal and mediator parts).

There is a hormone increasing - adrenaline up to 67 % and in a greater degree of mediator - (in 2 times) in 2 hours after physical activity that is explained by power resources mobilization. This directivity is increased in 10 hours after experiment.

The Rresearch of catecholamines’ biorhythms (excretion in separate portions of daily urine) has revealed that during the stress «pendulums of biological clocks» compensatory change with formation of excretion adrenaline peaks, noradrenaline and dopamine during the experiment on the background of predecessors’ reduction. As far as the term of experiment increasing the number with «morning type» working capacity decreases and the number of animals- arrhythmic accrues.

Infringements of catecholamine’ metabolism and monoamines have phase character: the predecessor intensively passes in noradrenaline on the background of serotonin reduction and excretion increasing of its metabolite 5- oxiindolacetic acid that is explained by metabolic hypoxia.

In 10 days of muscular work there is an accumulation of catecholamines (adrenaline and noradrenaline) in liver, owing to decrease of their inactivation in this organ’s tissue.

We observed staging and synchronization of catecholamines’ functional condition with excrection of 5-oxiindolacetic acid as a consequence of regulator mechanisms pressure that testifies to development of internal desynchrogenesis under the influence of physical activity. Sharper sympathetic shift on noradrenaline level can be regarded as critical both during urgent as long-term adaptation. Thus mobilization of biologically active substances is obligatory nonspecific reaction of an organism.

Histamine’s blood test showed that its level decreases in 2 hours after muscular exercise and in 10 hours – it gradually increases up to the top borders of physiological norm while serotonin level in blood progressively decreases on the background of increasing the disintegration’s products. Apparently, physical activity activates redistribution of monoamines balance as it is known that histamine and serotonin are united by metabolism including as their formation by means of amino acids and their inactivation using methylation and oxidizing deaminization.

The given results are confirmed by the analysis of intrasystem and intersystem communications and their correlation.