Ust-Kamenogorsk Titanium-Magnesium Plant is the one of the largest producers of spongy titanium accounting for approximately 20 per cent of the worldwide production.

The technological process of producing spongy titanium is accompanied by emitting toxic gases – hydrogen chloride, chlorine, magnesium chloride, titanium tetrachloride, titanium slag dust and titanium metal, its dioxide.

Specific attributes of the technological process under unfavorable working conditions evoke a danger of professional and non-specific diseases.

Bearing this in mind the leading specialties were examined: chlorine workers, electrolysis workers, mold workers, oven workers, which comprised the first group. The second group included production operative workers and workers with lesser degree of exposure. In the control group there were workers which were not exposed to professional hazards. In the workers’ blood of all investigated groups indexes of kinin-kallikrein system by T.C. Paschinoy and T.P. Egorovoy methods were defined: kininogen level – predecessor of free kinins, kininase – enzymes activity, which splits free kinins, kallikrein and its predecessor – kininogen.

The analysis of the findings have shown consistent changes in the enzymatic link of kallikrein – kinin system in the first group of the workers: kallikrein activity which produces free kinins from bradykininogen increased by 16%, that naturally caused increasing of kininase – enzymes activity which collapsing biologically active and free kinins by 28% (p<0,001). The second group workers which were more exposed to dust and gases, demonstrated increase in kallikrein activity by 44 % that was not compensated by kininase activity (inhibited by 20%), at the background of prekallikrein decrease by 20%.

In the workers of both groups there were differences in prekallikrein level, kininase and kallikrein activities.

Presumably, the changes in enzyme profile of kinin-kallikrein system in the first group might be considered as physiological modification, whereas the second group might be referred as the group where functioning of kallikrein – kinin system is inhibited not only on behalf of enzyme link but also its substrates causing changes in the vascular system due to impact of dust and gases.