Nowadays environmental pollution due to anthropogenic impact presents a very serious problem, which requires studying biological effects in conditions of experimental simulation.

In studying pathogenesis of a number of morbid conditions kinin–kallikrein system (KKS) is given a great consideration. It is explained by high biological potency of kinins, their strong spectrum activity, close interaction of this system and other blood proteolytic systems (hemocoagulating, fibrinolysis, rennin-angiotensiny, complement), responsible for maintenance of hemodynamic balance, vascular tone and involved into the resistance system of the organism. According to different morbid conditions there is a disorder of KKS adaptive regulator function therefore the identification of its activity is an important moment in studying pathogenesis of heavy metal intoxication and the choice of its correction with different phytogenous medicine.

Purpose: investigating the influence of the drug “Salsocollin” on the state of kinin–kallikrein system in the blood of white rats under their intoxication with nickel chloride.

Materials and methods: 30 white male rats with the weight 170–200g were divided into 3 groups: in the first group (n=10) there were intact animals, in the second group (n=10) there were animas with intake of NiCL2 (21 mg/kg) once per os, the third group (n=10) – with intake of 50 mg/kg of “Salsocollin” and NiCL2 (21 mg/kg). Kinin–kallikrein system content was determined by the method of V.A. Goncharova. “Salsocollin” was made from Salsola collina Pall in the Institute of Phytochemistry of the MES RK (Ministry of Education and Science, Republic of Kazakhstan).

Results: State of kallikrein in blood increased in 24 hours after NiCL2 was given, in comparison with blood value of intact animals it increased from 82,3 ± 3,4 to 98,4 ± 4,8 McU/ml (р<0,05), according to this background significant decreasing of prekallikrein state in the blood of the animals was from 59,1 ± 1,0 to 46,2 ± 1,4 McU/ml (р<0,001). Normalization tendency of kallikrein state (85,1 ± 5,2 McU/ml) in blood became evident in 24 hours under influence of NiCL2 on the background of “Salsocollin” according to this fact there was significant elevation of prekallikrein state (56,2 ± 1,9 McU/ml) in the blood.

Discussion and conclusion: Acute exposure to NiCL2 is characterized by changes of the indexes of kallikrein-kinin system, which can be explained by a nonspecific response of the vascular system to the mental stress. Modifying effect of “Salsocollin” is explained by inhibition processes of free-radical oxidation.